Your browser doesn't support javascript.
loading
Vitamin D receptor (FokI, BsmI and TaqI) gene polymorphisms and type 2 diabetes mellitus : A North Indian study.
Indian J Med Sci ; 2009 May; 63(5) 187-194
Article em En | IMSEAR | ID: sea-145406
Background : The vitamin D receptor (VDR) gene is a candidate gene for susceptibility to several diseases. Studies on association between VDR polymorphisms and risk of type 2 diabetes (T2DM) in different ethnic populations are yet inconclusive. Aims : This study was conducted to evaluate association between VDR polymorphisms and genetic susceptibility to T2DM in the north Indian population. Settings and Design : One hundred clinically diagnosed T2DM patients and 160 healthy controls from the north Indian population were recruited for genetic association study. Materials and Methods : Genomic DNA was extracted from blood and genotyped for the single nucleotide polymorphism SNPs of FokI (T/C) [rs2228570], BsmI (A/G) [rs1544410] and TaqI (C/T) [rs731236] by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis. Statistical Analysis Used : Genotype distribution and allelic frequencies were compared between patients and controls. Mean values and odds ratios (ORs) with 95% confidence interval (CI) were calculated using SPSS software (version 15.0). Results : The genotype distribution, allele and haplotype frequencies of VDR polymorphism did not differ significantly between patients and controls. Mean age and waist-hip ratio of patients were found to be associated with VDR polymorphism. Combination studies showed FFBbtt increased the risk of T2DM in north Indians. Conclusions : Our data suggest that VDR gene polymorphism in combination of genotypes is associated with the risk of T2DM and thus requires further studies as a probable genetic risk marker for T2DM.
Assuntos
Palavras-chave
Texto completo: 1 Índice: IMSEAR Assunto principal: Humanos / Reação em Cadeia da Polimerase / Receptores de Calcitriol / Predisposição Genética para Doença / Polimorfismo de Nucleotídeo Único / Diabetes Mellitus Tipo 2 / Frequência do Gene / Genótipo / Índia / Pessoa de Meia-Idade País/Região como assunto: Asia Idioma: En Revista: Indian J Med Sci Ano de publicação: 2009 Tipo de documento: Article
Texto completo: 1 Índice: IMSEAR Assunto principal: Humanos / Reação em Cadeia da Polimerase / Receptores de Calcitriol / Predisposição Genética para Doença / Polimorfismo de Nucleotídeo Único / Diabetes Mellitus Tipo 2 / Frequência do Gene / Genótipo / Índia / Pessoa de Meia-Idade País/Região como assunto: Asia Idioma: En Revista: Indian J Med Sci Ano de publicação: 2009 Tipo de documento: Article