Prevalence of Common Infections and Flare-ups in on-treatment SLE Patients Attending Two Tertiary Care Hospitals in Kolkata
J Indian Med Assoc
; 2022 Jan; 120(1): 22-25
Article
| IMSEAR
| ID: sea-216473
ABSTRACT
Systemic Lupus Erythematosus (SLE) is a multisystem autoimmune disease. Infections are the most common complications. Early detection, proper management of infection and its differentiation from Lupus flare are of paramount importance. Objective:
To find out the prevalence of infections with various etiologic agents among on-treatment SLE patients who were hospitalized for suspected infections and to differentiate infections from disease flare.Methods:
This was a cross-sectional observational study with 50 patients of more than 16 years of age of both sexes fulfilling the Systemic Lupus International Collaborating Clinics (SLICC) 2012, classification criteria of SLE who were admitted for suspected infection as manifested by fever and systemic symptoms. Specific tests to identify etiological agent for infection were performed and the condition was differentiated from lupus flare with the help of the tests such as Total Leucocyte Count (TLC), C-reactive Protein (CRP), Anti-ds DNA, complements-C3 and C4.Result:
Infections were evident in 42 patients (84%) with predominant monoinfection being pneumonia in 13 patients (30.9%) followed by Urinary Tract Infection (UTI) in 8 patients (19%). Streptococcus pneumoniae was the major cause of Pneumonia while Escherichia coli caused most of UTIs. The infection markers were fever, CRP and TLC. Of the 42 patients, 40 patients (95%) had fever, 28 (66.7%) had Leukocytosis and 35 (83%) had CRP 10 mg/L or more indicating infection. Anti-ds DNA antibody was raised in 4 patients out of total 6 patients with Lupus flare. The complements C3 and C4 values were low in all the 6 patients. No patient of disease flare had raised CRP or LeukocytosisConclusion:
Among 50 on-treatment SLE patients who were admitted in two Tertiary Care Hospitals of Kolkata with suspected infection it was found that 42 patients were having infections and 6 patients were suffering from Lupus flare. The predominant monoinfection was Pneumonia followed by UTI.
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J Indian Med Assoc
Ano de publicação:
2022
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Article