Lack of association between CSF nitrate and sera nitrate in falciparum malaria infection.
Southeast Asian J Trop Med Public Health
; 2001 Jun; 32(2): 268-74
Article
em En
| IMSEAR
| ID: sea-34455
ABSTRACT
Nitrate levels in CSF and sera from 16 coma and 19 noncoma falciparum malaria patients were determined using nitric oxide colorometric assay. The medians (range lower, upper limits) of nitrate in sera of comatose and noncomatose patients were 0.28 (0.11, 1.24) and 0.23 (0.05, 0.87) microM, respectively. The medians of nitrate level in CSF of coma and noncoma cases were 0.09 (0.01, 0.28) and 0.15 (0, 1.18) microM, respectively. There was no difference of nitrate level in sera and CSF from comatose or noncomatose patients compared to that in normal sera and CSF. The amount of nitrate in sera and CSF of both groups was not significantly correlated with coma depth, parasitemia, parasite clearance time and time to recovery. Contrast to our in vitro study using immunoperoxidase staining, we found inducible nitric oside synthase production by brain endothelial cells during 4-24 hours of coculturing with late stage of P. falciparum infected red blood cells. These results suggests that malaria severity can not be differentiated by nitrate level in body fluid.
Texto completo:
1
Índice:
IMSEAR
Assunto principal:
Plasmodium falciparum
/
Tailândia
/
Feminino
/
Humanos
/
Masculino
/
Endotélio Vascular
/
Células Cultivadas
/
Adolescente
/
Malária Falciparum
/
Coma
País/Região como assunto:
Asia
Idioma:
En
Revista:
Southeast Asian J Trop Med Public Health
Ano de publicação:
2001
Tipo de documento:
Article