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Gastrointestinal stromal tumors (GISTs): a pathology view point.
Article em En | IMSEAR | ID: sea-39269
ABSTRACT
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract. Most gastrointestinal soft tissue neoplasms, previously classified as leiomyomas, schwannomas, leiomyoblastomas, or leiomyosarcomas, are now classified as GISTs based on histology, immunohistochemistry, and molecular study. They originate from the stem cells that differentiate toward the pacemaker cell (Interstitial cell of Cajal). Prognostic factors have been identified for GISTs and include tumor size and mitotic rate. Surgery is the standard treatment for resectable GISTs. Metastatic and inoperable GISTs should be considered the medication with tyrosine kinase inhibitor (imatinib mesylate), which inhibits the c-kit receptor. The role of the pathologist in the differential diagnosis of GISTs, as well as in the assessment of the malignant potential of the tumors, is becoming increasingly important in influencing decisions regarding clinical management of GISTs. The present paper reviews the literature of GISTs and emphasizes on the field of the pathologist's work.
Assuntos
Texto completo: 1 Índice: IMSEAR Assunto principal: Piperazinas / Prognóstico / Pirimidinas / Humanos / Imuno-Histoquímica / Biomarcadores Tumorais / Proteínas Proto-Oncogênicas c-kit / Tumores do Estroma Gastrointestinal / Inibidores de Proteínas Quinases / Diagnóstico Diferencial Tipo de estudo: Diagnostic_studies / Prognostic_studies Idioma: En Ano de publicação: 2009 Tipo de documento: Article
Texto completo: 1 Índice: IMSEAR Assunto principal: Piperazinas / Prognóstico / Pirimidinas / Humanos / Imuno-Histoquímica / Biomarcadores Tumorais / Proteínas Proto-Oncogênicas c-kit / Tumores do Estroma Gastrointestinal / Inibidores de Proteínas Quinases / Diagnóstico Diferencial Tipo de estudo: Diagnostic_studies / Prognostic_studies Idioma: En Ano de publicação: 2009 Tipo de documento: Article