Effect of glutamine analogue-acivicin on tumor induced angiogenesis in Ehrlich ascites carcinoma.
Indian J Exp Biol
; 2005 May; 43(5): 407-13
Article
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| ID: sea-57393
ABSTRACT
The inhibition of tumor growth and tumor induced angiogenesis by the glutamine antimetabolite acivicin was evaluated in 6-7 weeks old male Swiss albino mice bearing Ehrlich ascites carcinoma (EAC) transplanted by intraperitoneal (ip) injections of EAC cells. Treatment involving ip injections with two different doses of acivicin (0.05 and 0.41microg/g body weight/day) in saline revealed decrease in tumor volumes and reduced number of blood vessels on peritoneal wall after 10 and 15 days of treatment when compared to control (i.e. injected with saline only). Vascular hyperpermeability was found to be lesser in the treated groups of mice than the control as indicated by the FITC- D and colloidal carbon assay. Serum VEGF level was found to decrease in the drug treated groups both after 10 and 15 days of treatment. The results thus suggest that acivicin may suppress tumoral angiogenesis through regulation of VEGF level.
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Assunto principal:
Masculino
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Carcinoma de Ehrlich
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Inibidores da Angiogênese
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Isoxazóis
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Animais
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Camundongos
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Neovascularização Patológica
Idioma:
En
Revista:
Indian J Exp Biol
Ano de publicação:
2005
Tipo de documento:
Article