Effect of mycotoxins isolated from Penicillium nigricans on glucose-6-phosphate dehydrogenase.
Indian J Exp Biol
; 1997 Nov; 35(11): 1233-6
Article
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| IMSEAR
| ID: sea-57733
ABSTRACT
A new mycotoxin product (NMP) was isolated from the culture of mutated wild strain of P. nigricans which is less toxic and has sterol derivative. NMP (LD50 > 1 g/kg) showed antimicrobial and antineoplastic activities and does not affect the hematological parameters like RBC count and hemoglobin. It maintained normal blood glucose level by increasing the enzyme activity of glucose-6-phosphate dehydrogenase (EC-1.1.1.49; G-6-PDH) by 30%. It also maintained the normal ion balance in the blood of mice. NMP decreased Km value of glucose-6-phosphate dehydrogenase and thus increased substrate affinity of the enzyme. Reduction of toxicity of NMP has been well explained by higher activity of G-6-PDH which is highly specific for production of NADPH.
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Assunto principal:
Penicillium
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Cinética
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Antraquinonas
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Glucosefosfato Desidrogenase
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Animais
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Camundongos
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Micotoxinas
Idioma:
En
Revista:
Indian J Exp Biol
Ano de publicação:
1997
Tipo de documento:
Article