5-HT3 receptors in selective animal models of cognition.
Indian J Exp Biol
; 2002 Feb; 40(2): 174-80
Article
em En
| IMSEAR
| ID: sea-57937
ABSTRACT
Role of 5-HT3 receptors in cholinergic hypofunctional models of cognitive impairment in the elevated plus maze model and a passive avoidance model is studied. Cognitive impairment was caused by scopolamine (1 mg/kg, ip) in mice and 5-HT3 ligands mCPBG (1 and 5 mg/kg, ip) and ondansetron (0.5 and 5 mg/kg, ip) were administered before the pre-learning phase to study the effects on acquisition, while post-learning administration was used to determine the effects on consolidation. Ondansetron improved acquisition and retention in cholinergic hypofunctional models while mCPBG potentiated selected impaired cognitive indices. The results indicate the role of 5-HT3 receptors in cognition and that an ideal evaluation of 5-HT3 ligands in cognition should distinguish true cognitive effects from locomotor, motivational and emotional effects.
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Assunto principal:
Escopolamina
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Antagonistas da Serotonina
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Biguanidas
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Masculino
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Transdução de Sinais
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Receptores de Serotonina
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Ondansetron
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Cognição
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Aprendizagem em Labirinto
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Receptores 5-HT3 de Serotonina
Idioma:
En
Revista:
Indian J Exp Biol
Ano de publicação:
2002
Tipo de documento:
Article