Inhibition of selenium dependent glutathione peroxidase and superoxide dismutase in rats by diethyldithiocarbamate: effect of pre-administration of alpha-tocopherol.
Indian J Exp Biol
; 2007 May; 45(5): 465-8
Article
em En
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| ID: sea-60172
ABSTRACT
Rats pre-administered with alpha-tocopherol (10 mgs/day) for 7 days afforded a significant protection at the tissue level against the lowering of superoxide dismutase and glutathione peroxidase, especially the selenium-dependent glutathione peroxidase. The protective action of alpha-tocopherol in the diethyldithiocarbamate treated rats may be attributed to its antioxidant/free radical scavenging action. It is concluded that selenium-dependent glutathione peroxidase and alpha-tocopherol act in a complementary fashion to block free radical formation.
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Índice:
IMSEAR
Assunto principal:
Ratos
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Superóxido Dismutase
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Fatores de Tempo
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Masculino
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Ratos Wistar
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Ditiocarb
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Citoproteção
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Alfa-Tocoferol
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Radicais Livres
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Glutationa Peroxidase
Tipo de estudo:
Evaluation_studies
Idioma:
En
Revista:
Indian J Exp Biol
Ano de publicação:
2007
Tipo de documento:
Article