Collagen profile in isoproterenol induced myocardial necrosis in rats.
Indian J Exp Biol
; 1998 Aug; 36(8): 763-7
Article
em En
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| ID: sea-60677
ABSTRACT
Studies on collagen in heart are important to understand the pathogenesis of myocardial necrosis and to evaluate cardiac function in infarcted heart. The present study has been undertaken to find out the alterations in collagen types in heart as well as serum proteins during myocardial injury in rats. A decreased collagen content was observed on day one which may be due to increased secretion of collagenase and proteases from inflammatory cells or from the myocardium. The changes noticed in the collagen types (I, III and V) indicated the altered elasticity of the heart. Histological studies were observed to correlate well with the biochemical changes in collagen. Evaluation of myocardial collagen could provide new approaches to the treatment of infarct size reduction.
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IMSEAR
Assunto principal:
Ratos
/
Feminino
/
Colágeno
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Ratos Wistar
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Coração
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Isoproterenol
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Animais
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Miocárdio
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Necrose
Idioma:
En
Revista:
Indian J Exp Biol
Ano de publicação:
1998
Tipo de documento:
Article