Low incidence of CNS relapse with cranial radiotherapy and intrathecal methotrexate in acute lymphoblastic leukemia.
Indian Pediatr
; 1996 Jul; 33(7): 556-60
Article
em En
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| ID: sea-6223
ABSTRACT
OBJECTIVES:
To assess the incidence of isolated central nervous system (CNS) relapses in patients of acute lymphoblastic leukemia (ALL) treated with a protocol containing cranial irradiation and intrathecal methotrexate as CNS directed therapy.DESIGN:
Prospective non randomized study.SETTING:
Department of Medical Oncology, Tata Memorial Hospital.SUBJECTS:
623 children of ALL on MCP 841.METHODS:
CNS relapse was diagnosed, if upon examination of the CSF, more than 50 cells/microliter were observed, or a count of 5 cells which were unequivocally lymphoblasts.RESULTS:
The incidence of isolated CNS relapse was 1.75% with the use of this treatment. Age, sex, white blood cell count, platelet count, lactic dehydrogenase and immunophenotyping were not significantly related to isolated CNS relapse.CONCLUSION:
A low incidence of isolated CNS relapse demonstrates the adequacy of the presymptomatic CNS therapy.
Texto completo:
1
Índice:
IMSEAR
Assunto principal:
Feminino
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Humanos
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Masculino
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Sistema Nervoso Central
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Criança
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Pré-Escolar
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Metotrexato
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Irradiação Craniana
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Adolescente
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Infiltração Leucêmica
Tipo de estudo:
Clinical_trials
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Guideline
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Incidence_studies
Idioma:
En
Revista:
Indian Pediatr
Ano de publicação:
1996
Tipo de documento:
Article