Influence of acidic beverage (Coca-Cola) on pharmacokinetics of ibuprofen in healthy rabbits.
Indian J Exp Biol
; 2003 Nov; 41(11): 1322-4
Article
em En
| IMSEAR
| ID: sea-62950
ABSTRACT
The study was aimed at determining the effect of Coca-Cola on the pharmacokinetics of ibuprofen in rabbits. In a cross-over study, ibuprofen was given orally in a dose of 56 mg/kg, prepared as 0.5% suspension in carboxymethyl cellulose (CMC) and blood samples (1 ml) were drawn at different time intervals from 0-12 hr. After a washout period of 7 days, Coca-Cola in a dose of (5 ml/kg) was administered along with ibuprofen (56 mg/kg) and blood samples were drawn from 0-12 hr. To these rabbits, 5 ml/kg Coca-Cola was administered once daily for another 7 days. On 8th day, Coca-Cola (5 ml/kg) along with ibuprofen (56 mg/kg), prepared as a suspension was administered and blood samples (1 ml each) were drawn at similar time intervals. Plasma was separated and assayed for ibuprofen by HPLC technique and various pharmacokinetic parameters were calculated. The Cmax and AUC0-alpha of ibuprofen were significantly increased after single and multiple doses of Coca-Cola, thereby indicating increased extent of absorption of ibuprofen. The results warrant the reduction of ibuprofen daily dosage, frequency when administered with Coca-Cola.
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1
Índice:
IMSEAR
Assunto principal:
Coelhos
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Masculino
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Bebidas Gaseificadas
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Disponibilidade Biológica
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Anti-Inflamatórios não Esteroides
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Ibuprofeno
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Administração Oral
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Cromatografia Líquida de Alta Pressão
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Interações Alimento-Droga
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Estudos Cross-Over
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Indian J Exp Biol
Ano de publicação:
2003
Tipo de documento:
Article