Influence of histamine and H1-receptor antagonists on ejaculated human spermatozoa: role of intrasperm Ca2+.
Indian J Exp Biol
; 2004 May; 42(5): 481-5
Article
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| ID: sea-63299
ABSTRACT
Histamine reduced sperm viability in a dose- and time-dependent manner, accompanied by rise in intrasperm Ca2+. Further, 2',4'-dichlorobenzamil hydrochloride (DBZ), a Na+-Ca2+ exchange inhibitor, known to elevate intrasperm Ca2+, potentiated both, elevation of intrasperm Ca2+ and spermicidal action of histamine. Pretreatment of sperm with very low doses of H1-receptor antagonists (chlorpheniramine, promethazine or diphenhydramine) prevented the histamine-induced elevation of intrasperm Ca2+ as well as its spermicidal action. However, pretreatment with famotidine, a H2-receptor antagonist did not produce such a protective action. The results strongly suggest that histamine elicits its spermicidal action via H1-receptors present on sperm cells.
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Assunto principal:
Prometazina
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Motilidade dos Espermatozoides
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Espermatozoides
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Fatores de Tempo
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Humanos
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Masculino
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Histamina
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Sobrevivência Celular
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Clorfeniramina
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Cálcio
Idioma:
En
Revista:
Indian J Exp Biol
Ano de publicação:
2004
Tipo de documento:
Article