Long-term anti-inflammatory drug use and Helicobacter pylori infection: a clinical, endoscopic and histological study.
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| ID: sea-64127
ABSTRACT
BACKGROUND:
Non-steroidal anti-inflammatory drugs (NSAIDs) and Helicobacter pylori are independent risk factors for gastroduodenal damage and peptic ulcer.OBJECTIVE:
To study the frequency and effect of H pylori infection on gastroduodenal mucosa in patients on long-term NSAID use.METHODS:
A total of 125 subjects were studied 65 patients (Group 1) on NSAID therapy (> 6 months), 30 patients (Group 2) with arthritic disorders prior to starting NSAID therapy, and 30 healthy volunteers (Group 3). Dyspeptic symptoms were evaluated using a questionnaire. All patients underwent endoscopy and antral and duodenal biopsies were obtained to assess the extent of gastroduodenal damage and H pylori status.RESULTS:
H pylori infection was less frequent in Group 1 (37%) compared to Group 2 (57%, p = ns) and 3 (60%, p < 0.05). Among Group 1 patients, H pylori infection did not increase the risk of gastroduodenal damage (52% vs 45%) or ulceration (32% vs 27%). Group 1 patients with H pylori infection were more likely to be symptomatic (48% vs 27%) and have chronic active gastritis (76% vs 12%) and chronic active duodenitis (68% vs 5%). Gastric metaplasia was seen only in patients with H pylori infection, chronic active gastritis and duodenitis. Chemical gastritis was observed more commonly in Group 1 (34% vs 3%) compared to Group 2; its was not seen in Group 3. H pylori infection was less commonly observed in patients with chemical gastritis (8% vs 50%).CONCLUSION:
Patients on long-term NSAIDs are not at increased risk of H pylori infection. Presence H pylori infection is not associated with increased risk of gastroduodenal damage in these patients. H pylori infection correlated with presence of chronic active gastritis, and NSAID with presence of chemical gastritis.
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Índice:
IMSEAR
Assunto principal:
Úlcera Péptica
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Humanos
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Fatores de Risco
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Helicobacter pylori
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Infecções por Helicobacter
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Endoscopia
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Mucosa Gástrica
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Gastrite
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Anti-Inflamatórios
Tipo de estudo:
Etiology_studies
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Risk_factors_studies
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article