Effect of a short course of indomethacin on gastric mucosal blood flow using endoscopic laser-Doppler velocimetry.
Article
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| ID: sea-65471
ABSTRACT
OBJECTIVE:
To assess the effect of a short course of indomethacin on gastric mucosal blood flow (GMBF).METHODS:
Patients with musculo-skeletal pain of recent origin and were prescribed a short course of therapy with indomethacin (25 mg tid for 7 days) were studied Baseline measurements of GMBF were carried out using endoscopic laser-Doppler velocimetry prior to starting indomethacin. At sites on the antrum, incisura, lesser and greater curvatures, and fundus. GMBF measurements were repeated after indomethacin therapy, as above and also on sites of erosions, it any.RESULTS:
Baseline GMBF at sites on the antrum, incisura, greater and lesser curvatures, and fundus were (mean) 8.6, 7.9, 8.8, 8.5 and 8.7 volts, respectively. Post-therapy values did not differ from the corresponding baseline values (8.7, 8.5, 8.6, 8.6 and 8.3 volts, respectively). However, ten of the 16 patients developed gastric mucosal erosions and the mean GMBF on these sites of erosion was significantly reduced (6.6 +/- 1.3 volts, p < 0.05).CONCLUSIONS:
A short course of indomethacin therapy produces a patchy decrease in blood flow in the gastric mucosa and erosions were seen in these areas.
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Índice:
IMSEAR
Assunto principal:
Fluxo Sanguíneo Regional
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Feminino
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Humanos
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Masculino
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Anti-Inflamatórios não Esteroides
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Indometacina
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Gastroscopia
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Fluxometria por Laser-Doppler
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Adulto
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Depressão Química
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article