Effect of tense ascites on esophageal body motility and lower esophageal sphincter pressure.
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| ID: sea-65561
ABSTRACT
BACKGROUND:
Esophageal motility and lower esophageal sphincter (LES) pressure change with rapid changes in intraabdominal pressure (IAP); the response of these to slow change in IAP is not known.AIMS:
To study esophageal body motility and LES pressures in patients with cirrhosis with tense ascites in the basal state and after paracentesis.METHODS:
Twenty four patients with cirrhosis of liver and tense ascites and 13 with cirrhosis without ascites (controls) were studied. Basal intragastric (IGP) and LES pressures, and esophageal body response to water swallows, were recorded using a water perfusion system; IAP was measured in patients with ascites. In patients with ascites, the study was repeated twice after paracentesis of two liters of fluid and after adequate control of ascites.RESULTS:
Basal IGP (p = 0.002) and duration of esophageal contraction (p = 0.01) were lower in controls, but basal LES pressures were similar in the two groups. After control of ascites, IAP (p = 0.02) and IGP (p = 0.005) decreased; amplitude and duration of distal esophageal contraction decreased (p < 0.05). The frequency of high-amplitude waves also decreased (p = 0.04). LES pressure remained unaltered.CONCLUSIONS:
Esophageal contraction duration is increased in the presence of ascites, and decreases after control of ascites; LES pressure is not affected by ascites.
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Assunto principal:
Peristaltismo
/
Pressão
/
Ascite
/
Feminino
/
Humanos
/
Masculino
/
Estudos de Casos e Controles
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Estudos Prospectivos
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Paracentese
/
Junção Esofagogástrica
Tipo de estudo:
Observational_studies
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article