Usefulness of anti -CCP antibodies in rheumatic diseases in Indian patients.
Indian J Med Sci
; 2009 Mar; 63(3): 92-100
Article
em En
| IMSEAR
| ID: sea-67504
ABSTRACT
BACKGROUND:
The usefulness of anti-cyclic citrullinated peptide antibodies (anti-CCP antibodies) to identify rheumatic arthritis (RA) from other rheumatic diseases presenting with joint pain is not well studied.AIMS:
We aimed to determine the sensitivity and specificity of anti-CCP antibodies in Indian RA patients with respect to non-RA rheumatic diseases and to study the relationship of anti-CCP antibodies and IgG, IgM and IgA rheumatoid factor in RA. SETTINGS ANDDESIGN:
Case-control cross-sectional study carried out in the rheumatology division of All India Institute of Medical Sciences. MATERIALS ANDMETHODS:
Sixty-three patients with rheumatoid arthritis (RA) and 51 patients with non-RA rheumatic diseases having joint pain were included in the study. Sera were tested for anti-CCP antibodies (IgG) and IgA, IgM, IgG rheumatoid factor, using a commercially available enzyme-linked immunosorbent assay. STATISTICALANALYSIS:
Statistical analysis was performed using SPSS statistical software version 11.5.RESULTS:
Fifty-four of 63 RA patients (85.71%) were positive for anti-CCP antibodies. In the non-RA group, anti-CCP antibody was positive in only 5 of 51 patients (9.8%). Our study found a sensitivity of 85% and a specificity of 90.19% with regard to the use of anti-CCP antibodies assay in patients with joint pain to correctly identify RA. Anti-CCP antibodies positive patients did not have more erosive disease. IgM-RF-positive patients had more erosion when compared to the IgM-RF-negative group. Thirty-two of 57 (56.1%) IgM-RF-positive patients had erosions, while no patient (0/6 patients) had erosions in the IgM-RF-negative group (P=0.01)CONCLUSION:
Anti-CCP antibodies have high sensitivity and specificity for diagnosis of RA, in Indian patients. Anti-CCP antibodies positive patients did not have more erosive disease in our study.
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Índice:
IMSEAR
Assunto principal:
Pacientes
/
Peptídeos Cíclicos
/
Artrite Reumatoide
/
Fator Reumatoide
/
Autoanticorpos
/
Humanos
/
Doenças Reumáticas
/
Sensibilidade e Especificidade
/
Adulto
/
Índia
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
País/Região como assunto:
Asia
Idioma:
En
Revista:
Indian J Med Sci
Ano de publicação:
2009
Tipo de documento:
Article