Proteomic characterization of platelet-derived extracellular vesicles induced by different activation pathways / 中国输血杂志

ABSTRACT

Activated platelets secrete bioactive molecules and extracellular vesicles. Platelet-derived extracellular vesicles(PEVs), which are rich in proteins, have become important mediators of intercellular communication and cargo exchange, being involved in not only hemostasis and thrombosis, but also in immunity and tissue repair. In past decades, many advances have been made in the isolation, characterization and application of PEVs. Platelet activation modes influence the proteomic features of formed extracellular vesicles. The activation ways may be closely related to functional differences. This review summarized the proteomics and functions of PEVs induced by different platelet activation pathways.