Adjunctive role of dual time point imaging in evaluating bone lesions with increased 18F-PSMA-1007 uptake
The Philippine Journal of Nuclear Medicine
; : 14-17, 2023.
Article
em En
| WPRIM
| ID: wpr-1006158
Biblioteca responsável:
WPRO
ABSTRACT
Background@#Non-specific focal uptake in the skeleton is a diagnostic pitfall on 18F-PSMA-1007 PET/CT, but adjunctive measures to aid interpretation of these lesions are currently lacking. We present two cases where dual time point imaging provided additional information. @*Case Presentation@#The first patient had a PI-RADS 3 lesion on MRI. No PSMA-avid abnormality was seen on PET, save for focal uptake in the right pubis with no anatomic correlate. Additional imaging showed a decrease in lesion SUV, and this was interpreted as benign. Another patient, diagnosed with prostate cancer, had multiple PSMA-avid pelvic foci. Two suspiciously malignant bone lesions had increasing SUV trend after dual time point imaging despite only faint sclerosis on CT. In contrast, one faint PSMA-avid lesion with no anatomic abnormality was read as benign after a decrease in SUV. A decrease in lesion SUV may point to a benign etiology, while an increase would heighten suspicion for malignancy. One possible molecular explanation is that a true PSMA-overexpressing lesion would bind to the tracer for a longer period than a false positive.@*Conclusion@#Dual time point imaging provides additional information that may be useful in the interpretation of non-specificskeletal lesions with increased 18F-PSMA-1007 uptake.
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WPRIM
Assunto principal:
Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada
Idioma:
En
Revista:
The Philippine Journal of Nuclear Medicine
Ano de publicação:
2023
Tipo de documento:
Article