Advances in Allogeneic Chimeric Antigen Receptor T Cells / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 967-972, 2023.
Article
em Zh
| WPRIM
| ID: wpr-1008154
Biblioteca responsável:
WPRO
ABSTRACT
Autologous chimeric antigen receptor(CAR)T-cell therapy has improved the prognosis of hematological malignancies.Nevertheless,allogeneic CAR-T cells have potential advantages over the autologous approach available on the market.However,allogeneic CAR-T cells may cause life-threatening graft-versus-host disease(GVHD)or be rapidly eliminated by the host immune system.In this review,we analyze the different sources of T cells for optimal allogeneic CAR-T cell therapy,describe the different approaches,and introduce the gene editing measures to produce allogeneic CAR-T cells with limited potential for GVHD and improved anti-tumor effect.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Linfócitos T
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Imunoterapia Adotiva
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Transplante de Células-Tronco Hematopoéticas
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Receptores de Antígenos Quiméricos
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Doença Enxerto-Hospedeiro
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Neoplasias
Limite:
Humans
Idioma:
Zh
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2023
Tipo de documento:
Article