Platelet-to-lymphocyte ratio as a biomarker for predicting coronary artery lesions in Chinese children with Kawasaki disease: a Meta analysis / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 1219-1226, 2023.
Article
em Zh
| WPRIM
| ID: wpr-1009872
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVES@#To systematically evaluate the value of the platelet-to-lymphocyte ratio (PLR) in predicting coronary artery lesions (CAL) in Chinese children with Kawasaki Disease (KD).@*METHODS@#A comprehensive search was conducted in databases including PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Wanfang Data, China Biomedical Literature Database, and China Science and Technology Journal Database from inception to December 2022. The quality of the included literature was assessed using the Newcastle-Ottawa Scale, and a Meta analysis was performed using Stata 15.1.@*RESULTS@#A total of ten published reports, involving 3 664 Chinese children with KD, were included in this Meta analysis, of whom 1 328 developed CAL. The Meta analysis revealed a sensitivity of 0.78 (95%CI 0.71-0.83), specificity of 0.71 (95%CI 0.61-0.80), overall diagnostic odds ratio of 8.69 (95%CI 5.02-15.06), and an area under the curve of the summary receiver operating characteristic of 0.82 (95%CI 0.78-0.85) for PLR in predicting CAL in the children with KD. The sensitivity, specificity, and area under the curve of summary receiver operating characteristic were lower for PLR alone compared to PLR in combination with other indicators. Sensitivity analysis demonstrated the stability of the Meta analysis results with no significant changes upon excluding individual studies. However, a significant publication bias was observed (P<0.001).@*CONCLUSIONS@#PLR demonstrates certain predictive value for CAL in Chinese children with KD.
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WPRIM
Assunto principal:
Doença da Artéria Coronariana
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Linfócitos
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Biomarcadores
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China
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Vasos Coronários
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Síndrome de Linfonodos Mucocutâneos
Limite:
Child
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Humans
País/Região como assunto:
Asia
Idioma:
Zh
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2023
Tipo de documento:
Article