Research progress on the roles of neurovascular unit in stroke-induced immunosuppression / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 662-672, 2023.
Article
em Zh
| WPRIM
| ID: wpr-1009926
Biblioteca responsável:
WPRO
ABSTRACT
A complex pathophysiological mechanism is involved in brain injury following cerebral infarction. The neurovascular unit (NVU) is a complex multi-cellular structure consisting of neurons, endothelial cells, pericyte, astrocyte, microglia and extracellular matrix, etc. The dyshomeostasis of NVU directly participates in the regulation of inflammatory immune process. The components of NVU promote inflammatory overreaction and synergize with the overactivation of autonomic nervous system to initiate stroke-induced immunodepression (SIID). SIID can alleviate the damage caused by inflammation, however, it also makes stroke patients more susceptible to infection, leading to systemic damage. This article reviews the mechanism of SIID and the roles of NVU in SIID, to provide a perspective for reperfusion, prognosis and immunomodulatory therapy of cerebral infarction.
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Texto completo:
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Índice:
WPRIM
Assunto principal:
Infarto Cerebral
/
Terapia de Imunossupressão
/
Acidente Vascular Cerebral
/
Células Endoteliais
/
Neurônios
Limite:
Humans
Idioma:
Zh
Revista:
Journal of Zhejiang University. Medical sciences
Ano de publicação:
2023
Tipo de documento:
Article