Lipocalin 2 in the Paraventricular Thalamic Nucleus Contributes to DSS-Induced Depressive-Like Behaviors / 神经科学通报·英文版
Neuroscience Bulletin
; (6): 1263-1277, 2023.
Article
em En
| WPRIM
| ID: wpr-1010615
Biblioteca responsável:
WPRO
ABSTRACT
The incidence rate of anxiety and depression is significantly higher in patients with inflammatory bowel diseases (IBD) than in the general population. The mechanisms underlying dextran sulfate sodium (DSS)-induced depressive-like behaviors are still unclear. We clarified that IBD mice induced by repeated administration of DSS presented depressive-like behaviors. The paraventricular thalamic nucleus (PVT) was regarded as the activated brain region by the number of c-fos-labeled neurons. RNA-sequencing analysis showed that lipocalin 2 (Lcn2) was upregulated in the PVT of mice with DSS-induced depressive behaviors. Upregulating Lcn2 from neuronal activity induced dendritic spine loss and the secreted protein induced chemokine expression and subsequently contributed to microglial activation leading to blood-brain barrier permeability. Moreover, Lcn2 silencing in the PVT alleviated the DSS-induced depressive-like behaviors. The present study demonstrated that elevated Lcn2 in the PVT is a critical factor for DSS-induced depressive behaviors.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Encéfalo
/
Doenças Inflamatórias Intestinais
/
Proteínas Proto-Oncogênicas c-fos
/
Núcleos da Linha Média do Tálamo
/
Lipocalina-2
/
Camundongos Endogâmicos C57BL
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Neuroscience Bulletin
Ano de publicação:
2023
Tipo de documento:
Article