Research progress of Mendelian randomization analysis in intensive care medicine / 中华危重病急救医学
Chinese Critical Care Medicine
;
(12): 1101-1105, 2023.
Artigo
em Chinês
| WPRIM
| ID: wpr-1010913
ABSTRACT
The condition of critically ill patients changes rapidly, involving pathological changes in multiple systems and organs throughout the body. Exploring the causal relationship of mechanisms can further reveal etiology, treatment, and prognosis of diseases. However, traditional prospective studies in the field of critical care are still subject to numerous limitations. As an emerging research method, Mendelian randomization (MR) analysis uses genetic variation to provide causal evidence for instrumental variables, which is expected to provide clues in critical diseases. This article systematically describes the research progresson the application of MR analysis in critical care medicine from four aspects the principle of MR analysis, the difference between MR analysis and randomized controlled trial (RCT), the use of MR analysis in the field of critical illness, and the possible methods of application, aiming to provide possible directions for the research in this field.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Projetos de Pesquisa
/
Variação Genética
/
Causalidade
/
Análise da Randomização Mendeliana
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Critical Care Medicine
Ano de publicação:
2023
Tipo de documento:
Artigo
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