2,3-Seco and 3-nor guaianolides fromAchillea alpina with antidiabetic activity / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 610-618, 2023.
Article
em En
| WPRIM
| ID: wpr-1010974
Biblioteca responsável:
WPRO
ABSTRACT
In this study, we presented the isolation and characterization of eight novel seco-guaianolide sesquiterpenoids (1-8) and two known guaianolide derivatives (9 and 10), from the aerial part of Achillea alpina L.. Compounds 1-3 were identified as guaianolides bearing an oxygen insertion at the 2, 3 position, while compounds 4-8 belonged to a group of special 3-nor guaianolide sesquiterpenoids. The structural elucidation of 1-8, including their absolute configurations, were accomplished by a combination of spectroscopic data analysis and quantum electronic circular dichroism (ECD) calculations. To evaluate the potential antidiabetic activity of compounds 1-10, we investigated their effects on glucose consumption in palmitic acid (PA)-mediated HepG2-insulin resistance (IR) cells. Among the tested compounds, compound 7 demonstrated the most pronounced ability to reverse IR. Moreover, a mechanistic investigation revealed that compound 7 exerted its antidiabetic effect by reducing the production of the pro-inflammatory cytokine IL-1β, which was achieved through the suppression of the NLRP3 pathway.
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Texto completo:
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Índice:
WPRIM
Assunto principal:
Resistência à Insulina
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Citocinas
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Dicroísmo Circular
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Células Hep G2
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Glucose
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Hipoglicemiantes
Limite:
Humans
Idioma:
En
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Ano de publicação:
2023
Tipo de documento:
Article