Outcomes of reduced-intensity conditioning allogeneic hematopoietic stem cell transplantation for 10 patients with myelofibrosis / 中华血液学杂志
Chinese Journal of Hematology
; (12): 225-230, 2018.
Article
em Zh
| WPRIM
| ID: wpr-1011729
Biblioteca responsável:
WPRO
ABSTRACT
Objective:
To evaluate the efficacy of reduced-intensity conditioning allogeneic hematopoietic stem cell transplantation (RIC-allo-HSCT) for patients with myelofibrosis (MF).Methods:
The clinical data of 10 patients with myelofibrosis (MF) who underwent RIC-allo-HSCT.Results:
Of all 10 patients, 6 were male and 4 women, with a median age of 28.5 (22-54). Using fludarabine/busulfan plus total body irradiation (FB+TBI) pretreatment scheme based. Hematopoiesis reconstitution was achieved in 9 patients (90%). The median time of neutrophil and platelet engraftment was 13.5 (10-22) day and 16.5 (13-40) day, respectively. Acute GVHD occurred in 4 cases while chronic GVHD in 5 cases. The prospective OS for 3 years was (90.0±8.5)% after a median follow-up time of 17 months. Transplant related mortality was 1 case.Conclusion:
RIC-HSCT with FB+TBI is a feasible and effective alternative for MF patients.Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Vidarabina
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Bussulfano
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Estudos Prospectivos
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Transplante de Células-Tronco Hematopoéticas
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Condicionamento Pré-Transplante
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Mielofibrose Primária
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Doença Enxerto-Hospedeiro
Limite:
Adult
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Hematology
Ano de publicação:
2018
Tipo de documento:
Article