Research progress in design strategy and application of aptamers for targeted delivery of siRNA / 中国药理学通报
Chinese Pharmacological Bulletin
; (12): 1141-1146, 2022.
Article
em Zh
| WPRIM
| ID: wpr-1014026
Biblioteca responsável:
WPRO
ABSTRACT
RNA interference induced by small interfering (siR¬NA) has shown great potential in disease treatment.However, due to the poor stability of siRNA and lack of targeting, it is still challenging to deliver siRNA to target tissues/cells and induce gene silencing.Aptamer is a kind of oligonucleotide sequence that can specifically recognize the target.Covalently binding aptamers with siRNA or linking with other siRNA carriers can guide siRNA into target tissues/cells.In this review we summa¬ rize the research progress in the design strategy and application of aptamer-based targeted deliver)' of siRNA in the treatment of diseases in recent years, and discuss the challenges and pros-pects of aptamer-mediated siRNA deliver>r in clinical transforma¬tion.
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Índice:
WPRIM
Idioma:
Zh
Revista:
Chinese Pharmacological Bulletin
Ano de publicação:
2022
Tipo de documento:
Article