Discussion on the medication law of TCM compound patents in treating diabetic retinopathy based on data mining / 国际中医中药杂志

ABSTRACT

Objective:To explore the law of Chinese medicine patent compound prescription in treating diabetic retinopathy (DR).Methods:The patents of TCM compound for the treatment of DR Published in the patent database of China National Knowledge Resource Database (CNKI) from the establishment of the database to September 1, 2022 were searched and screened. The Ancient and Modern Medical Record Cloud Platform V2.0 was used to analyze the frequency of medication, nature, taste, and meridian distribution, and the rules of compatibility of medication were mined and analyzed based on association rules and cluster analysis.Results:A total of 113 compound patents were included, involving 201 kinds of Chinese materia medica. The top five drugs in frequency of use were Rehmanniae Radix, Notoginseng Radix et Rhizoma, Angelicae Sinensis Radix, Ganoderma and Astragali Radix. Their properties were mostly cold and warm, and their tastes were sweet and bitter. The top three meridians were liver meridian, lung meridian and kidney meridian. Six pairs of commonly used drugs were obtained, and four kinds of medicines were obtained by clustering analysis. Complex network analysis showed that core TCM combination was Rehmanniae Radix, Notoginseng Radix et Rhizoma, Angelicae Sinensis Radix, Ganoderma, Astragali Radix, Salviae Miltiorrhizae Radix et Rhizoma, Lycii Fructus, Prinsepiae Nux, and Cuscutae Semen.Conclusions:TCM compound patents for the treatment of DR are mainly used to treat cold and liver meridian, and the medication is mainly used to replenish qi and nourish yin, clear heat and cool blood, promote blood circulation and remove blood stasis, and tonify liver and kidney. The drug pairs are mainly used to supplement qi and nourish yin, clear heat and detoxify, invigorate qi and nourish blood, and invigorate qi and stop bleeding. The modified Danggui Buxue Decoction and Siwu Decoction are often used in treatment, and wind drugs are added as appropriate to soothe liver and improve eyesight, which can provide reference for clinic.