Association between Single Nucleotide Polymorphisms of alpha2A-, alpha2B-, and alpha2C-Adrenergic Receptor Genes and Risk of Cerebral White Matter Lesion / 대한뇌졸중학회지
Korean Journal of Stroke
; : 66-73, 2011.
Article
em Ko
| WPRIM
| ID: wpr-10203
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND: An alpha2-adrenergic receptor (alpha2-AR, ADRA2) mediates induction of hypotension and inhibition of lipolysis and insulin secretion. We evaluated whether single nucleotide polymorphisms (SNPs) of alpha2A (ADRA2A), alpha2B (ADRA2B), and alpha2C (ADRA2C) adrenergic receptors are associated with cerebral white matter lesion (cWML). METHODS: Total 336 study subjects who had no stroke were enrolled in this study. The Indices of cWML include total WML (TWML), periventricular WML (PVWML), and subcortical WML (SCWML) on brain fluid-attenuated inversion recovery (FLAIR) image. Common genetic variants of ADRA2A (1780G>A), ADRA2B (Ins/Del301-303), and ADRA2C (Ins/Del322-325) were examined. RESULTS: Among 336 study subjects, cWML was found in 66 patients (20%). In multivariate analysis, there were no significant effects of all tested ADRA2 polymorphisms on TWML. Significant association of ADRA2A 1780 AA genotype was found in PVWML (OR: 3.368, 95% CIs: 1.280-8.865, adjusted p-value after false discovery rate (FDR) correction=0.014) but not SCWML. CONCLUSION: Although SNPs of three ADRA2 subtypes failed to reach a significance in overall risk for cWML, the ADRA2A 1780G>A polymorphism may be associated with development of PVWML.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Encéfalo
/
Análise Multivariada
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Receptores Adrenérgicos
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Acidente Vascular Cerebral
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Polimorfismo de Nucleotídeo Único
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Genótipo
/
Hipotensão
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Insulina
/
Lipólise
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
Ko
Revista:
Korean Journal of Stroke
Ano de publicação:
2011
Tipo de documento:
Article