Relationship between serum matrix metalloproteinase-3 and cystatin C levels and pregnancy outcome in pregnant women with early-onset preeclampsia / 新乡医学院学报

ABSTRACT

Objective To investigate the predictive value of serum matrix metalloproteinase-3(MMP-3)and cystatin C(Cys C)levels and their combination for adverse pregnancy outcomes in patients with early-onset preeclampsia.Methods Thirty-one patients with early-onset preeclampsia admitted to the Department of Obstetrics in the First Affiliated Hospital of Bengbu Medical College from November 2021 to August 2022 were selected as the early-onset preeclampsia group,and 44 pregnant women with normal pregnancies who came to our hospital for labor and delivery during the same period were selected as the normal pregnancy group.Patients in the early-onset preeclampsia group were categorized into good pregnancy outcome group(n=13)and poor pregnancy outcome group(n=18)based on whether the pregnancy outcome was accompanied by a neonatal Apgar score of ≤ 7,intrauterine distress,fetal growth restriction,eclampsia seizures,and placental abruption.The levels of serum MMP-3 and cystatin C were detected by enzyme linked immunosorbent assay.The relationship between serum MMP-3,Cys C level and early-onset preeclampsia and pregnancy outcome were analyzed.The value of seurm MMP-3,cystatin C level and their combination in predicting adverse pregnancy outcomes in patients with early-onset preeclampsia were evaluated by using receiver operating characteristic.Results The levels of serum MMP3 and Cys C in the early-onset preeclampsia group were higher than those in the normal pregnancy group(P＜0.05).The levels of serum MMP-3 and Cys C in the poor pregnancy outcome group were higher than those in the good pregnancy outcome group(P＜0.05).The area unde the curve(AUC),sensitivity,specificity,Youden index of serum MMP-3 in predicting adverse pregnancy outcome in patients with early-onset preeclampsia were 0.885,83.3％,84.6％,0.679,respectively.The AUC,sensitivity,specificity,Youden index of serum Cys C in predicting adverse pregnancy outcome in patients with early-onset preeclampsia were 0.859,83.3％,76.9％,0.603,respectively.The AUC,sensitivity,specificity,Youden index of combined detection of serum MMP-3 and Cys C in predicting adverse pregnancy outcome in patients with early-onset preeclampsia were 0.923,72.2％,100％,0.722,respectively.Conclusion The serum MMP-3 and Cys C levels are overloaded in patients with early-onset preeclampsia,and the serum MMP-3 and serum Cys C levels are related to the pregnancy outcome of patients with early-onset preeclampsia.The combined detection of the two indexes can predict the adverse pregnancy outcome of early-onset preeclampsia to some extent.