Research progress in drug resistance and related mechanisms in Brucella / 中国人兽共患病学报

ABSTRACT

Brucellosis is a zoonosis with worldwide distribution,which is caused by bacteria of the genus Brucella.The in-cidence of brucellosis has recently increased each year,and caused great losses in terms of public health,animal husbandry and the social economy.Doxycycline plus rifampicin or streptomycin,the preferred antibiotic regimen,plays a key role in brucello-sis treatment.Because of the use of antibacterial drugs,Brucella has developed antimicrobial resistance,thus challenging clini-cal treatment.This article reviews research progress in drug resistance of Brucella from cattle and sheep(mainly Brucella abortus and Brucella melitensis)and Brucella from humans(mainly Brucella melitensis)from 2013 to 2023,including the types of antibiotic resistance,the rates of antibiotic resistance and the possible mechanism of antibiotic resistance,to provide a comprehensive reference for clinical the treatment of brucellosis and study of the drug resistance mechanisms of Brucella.