Surgical treatment decision and clinical value of molecularly defined renal carcinoma with highly aggressive behavior / 现代泌尿外科杂志
Journal of Modern Urology
; (12): 293-297, 2024.
Article
em Zh
| WPRIM
| ID: wpr-1031627
Biblioteca responsável:
WPRO
ABSTRACT
Molecularly defined renal carcinoma is a pathologic subtype of renal cell cancer (RCC) with a definite driver gene, which was first proposed in the 2022 WHO classification of tumors of the urinary system and male reproductive organs. The fumarate hydratase-deficient renal cell carcinoma and SMARCB1-deficient renal medullary carcinoma are highly aggressive and lethal subtypes. Due to the low incidence and lack of research on the mechanism, there is almost no effective treatment for these aggressive RCC subtypes. Cytoreductive nephrectomy or metastasectomy are important methods to improve the survival and quality of life of metastatic RCC patients under effective systemic therapy. However, for the highly aggressive RCC, the clinical value of the above surgical strategies is still unclear. In this review, we will discuss these problems in order to provide reference for the improvement of prognosis for patients with highly aggressive RCC subtypes.
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1
Índice:
WPRIM
Idioma:
Zh
Revista:
Journal of Modern Urology
Ano de publicação:
2024
Tipo de documento:
Article