Clinical observation on patients with severe head injury and herniation of brain administrated with naloxone after craniotomy / 中华神经医学杂志

ABSTRACT

Objective To explore the effect of naloxone (NLX) on patients with severe head injury and herniation of brain after the craniotomy. Methods A total of 108 patients with severe brain injury and herniation of brain were divided into 2groups: NLX group was treated with NLX and general therapy and control group was treated only by general therapy after the craniotomy. The abnormal respiration and heartbeat, recovery of consciousness at the early period and the prognosis at the later period were observed and all the data were analyzed statistically. Results The abnormal respiration and heartbeat of patients were significantly less in NLX group than in control group in the first 7d after injury(P<0.01). More patients revived in NLX group than in control group 14d and 1month after injury (P<0.05). The prognosis of NLX group was significantly better than that of control group 3months after injury (P<0.05). Conclusion The early administration of NLX in patients with severe head injury and herniation of brain after the craniotomy Can ameliorate the function of respiration and circulation, shorten the coma duration, reduce the incidence of disability and death, and improve the nerve function.