Recent advance in role and treatment of brain-derived neurotrophic factor imbalance in neurodegenerative diseases / 中华神经医学杂志

ABSTRACT

The two forms of brain-derived neurotrophic factor (BDNF), mature BDNF (mBDNF) and BDNF precursor (proBDNF), bind to corresponding receptors and mediate a series of biological signals, which play important roles in proliferation, survival and apoptosis. More and more studies have focused on the role of unbalanced transformation from proBDNF to mBDNF in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease, as well as their potential as biomarkers and treatment targets. This article reviews the mechanism and therapeutic application of BDNF and proBDNF/mBDNF imbalance in the above-mentioned neurodegenerative diseases to provide new perspective and approach for the pathogenesis, early diagnosis and treatment of neurodegenerative diseases such as AD and PD.