Glutamate and GABA concentrations in the cerebellum of novel ataxic mutant Pogo mice
Journal of Veterinary Science
; : 209-212, 2003.
Article
em En
| WPRIM
| ID: wpr-103639
Biblioteca responsável:
WPRO
ABSTRACT
The Pogo mouse is an autosomal recessive ataxic mutant that arose spontaneously in the inbred KJR/MsKist strain derived originally from Korean wild mice. The ataxic phenotype is characterized by difficulty in maintaining posture and side to side stability, faulty coordination between limbs and trunk, and the consequent inability to walk straight. In the present study, the cerebellar concentrations of glutamate and GABA were analyzed, since glutamate is a most prevalent excitatory neurotransmitter whereas gammar-aminobutyric acid (GABA) is one of the most abundant inhibitory neurotransmitters, which may be the main neurotransmitters related with the ataxia and epilepsy. The concentration of glutamate of cerebellum decreased significantly in ataxic mutant Pogo mouse compared to those of control mouse. However, GABA concentration was not decrease. These results suggested that the decrease in glutamate concentration may contribute to ataxia in mutant Pogo mouse.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Proteína G de Ligação ao Cálcio S100
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Imuno-Histoquímica
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Cerebelo
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Ácido Glutâmico
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Marcha Atáxica
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Ácido gama-Aminobutírico
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Camundongos Mutantes
Limite:
Animals
Idioma:
En
Revista:
Journal of Veterinary Science
Ano de publicação:
2003
Tipo de documento:
Article