Clinical Significance of Combined Detection of Serum Specific Autoanti-bodies in Systemic Lupus Erythematosus / 中国现代医生

ABSTRACT

Objective To explore the clinical significance of combined detection of anti-nucleosome(AnuA),anti-SM,anti-double-stranded DNA(ds-DNA),anti-ribosomal P protein(ARPA)antibodies in systemic lupus erythematosus(SLE). Methods 186 SLE patients and 89 rheumatic diseases patients were studied. Latter included. Results Tour kinds of masculine gender rates(86.5%)of antibody consociation ex-aminations were high to examine in the any and single item antibody in the SLE(62.7%, 50.0%, 28.4%, 15.7%)and were 9.0%, 11.2%,5.6%, 2.2% respectively in control groups. They were markedly higher than those of control groups(P< 0.05). The sero-positive rate of ds-DNA an-tibody was markedly higher than anti-SM antibody and ARPA in SLE patients with negative AnuA(P< 0.05). The sero-positive rate of AnuA was markedly higher than other two antibody in SLE patients with negative ds-DNA antibody ,anti-SM, antibody and ARPA respectively(P< 0.05). Conclusion Combination of AnuA,anti-SM,ds-DNA and ARPA antibodies can significantly improve the precision in diagnosis of SLE.