Changes of CD64, serum procalcitonin and C-reactive protein in periph-eral blood neutrophil of patients with respiratory tract infection before and after treatment / 中国现代医生

ABSTRACT

Objective To analyze the changes of CD64, serum procalcitonin and C-reactive protein in the peripheral blood neutrophil of patients with respiratory tract infection before and after treatment. Methods Eighty patients with respiratory tract infection were treated in our hospital from November 2012 to October 2013 , of which 42 cases clini-cally diagnosed by bacterial infection as group A , and 38 cases diagnosed by virus infection as group B ,and 40 healthy people selected as control group. Group A and group B were treated with routine treatment for 1 weeks. CD64 , PCT and CRP expression were detected by the methods of flow cytometry,immunofluorescence assay,and rapid immune fluorescence before and after treatment for 3 days and 7 days ,respectively.The differences of specificity and sensitivity were compared by analyzing the results of three methods. Results Before treatment,CD64, PCT, CRP levels of group A were (2611.5±252.4) MESF,(5.2±2.5) ng/mL, (60.5±13.4) mg/L, respectively, significantly higher than those of group B and control group (P<0.05); CD64 and CRP of group B were higher than those of control group (P<0.05);However, PCT compared with the control group, there was no significant difference (P>0.05). After treatment for 7 days, CD64 of group A decreased significantly, and the degree of bacterial infection decreased,as well as PCT and CRP compared with those after treatment for 3 days (P<0.05),and CD64 of group B showed a decreased trend, while PCT, CRP did not change significantly (P>0.05). The sensitivity,specificity and diagnostic efficiency of CD64 were 95.6%,92.4%,97.6%,respectively,was higher than those of PCT and CRP (P<0.05);But those between PCT and CRP had no significant difference (P>0.05). Conclusion CD64 expression of patients with bacterial infection of respiratory tract infection increased,and positively correlated with the respiratory tract bacterial infection rate,and specificity and sensitivity were higher than those of CRP.When compared with procalcitonin ,CD64 is more sensitive to reflect the severity of disease,and can observe the curative effect and guide clinical medication.