Correlation between serum S100β and NSE levels and vascular dementia in patients with acute cerebral infarction / 中风与神经疾病杂志

ABSTRACT

@#Objective　To investigate the relationship of serum astrocyte-derived protein (S100β) and neuron-specific enolase (NSE) in patients with acute cerebral infarction and vascular dementia (VD) and their predictive value.Methods　One hundred and thirty-two patients with acute cerebral infarction (cerebral infarction group) and 60 healthy people who took medical examinations (healthy control group) were collected and levels of serum S100β and NSE were detected by ELISA Patients with cerebral infarction were divided into the non-VD group and VD group according to the Mini Mental State Examination Scale (MMSE) score after 3 months’ treatment Logistic regression was used to analyze the correlation between S100β and NSE and the incidence of VD and ROC curve analysis was used to analyze the early predictive value of S100β and NSE levels for VD.Results　Compared with the healthy control group.the serum levels of S100β and NSE in the cerebral infarction group were significantly increased (P<0.05) and those in the VD group were significantly higher than the non-VD group (P<0.05).Multivariate logistic regression analysis showed that high S100β and high NSE were independent risk factors for VD after cerebral infarction.The sensitivity.specificity and accuracy of S100β and NSE for predicting VD after cerebral infarction were 75.86%,60.19%,63.64% and 68.97%,79.61%,77.27%,respectively.The sensitivity.specificity and accuracy of the combination of the S100β and NSE were 72.41%,90.29%,86.36%,respectively.Conclusion　High levels of S100β and NSE in serum were independent risk factors for VD after cerebral infarction,and the combined diagnosis of S100β and NSE has potential clinical value in predicting the occurrence of VD after cerebral infarction.