The memory ameliorating effects of novel N‑benzyl pyridine‑2‑one derivatives on scopolamine‑induced cognitive deficits in mice / 한국실험동물학회지
Laboratory Animal Research
; : 104-114, 2024.
Article
em En
| WPRIM
| ID: wpr-1044990
Biblioteca responsável:
WPRO
ABSTRACT
Background@#Alzheimer’s disease (AD), the most common form of progressive dementia in the elderly, is a chronic neurological disorder that decreases cognitive ability. Although the underlying cause of AD is yet unknown, oxidative stress and brain acetylcholine shortage are the key pathogenic causes. @*Results@#The current study shows that these derivatives have the potential to improve memory in mice by inhibiting scopolamine-induced acetylcholinesterase activity, oxidative and nitrosative stress, and improving locomotor activity and muscle grip strength in the rota rod test. When compared to the illness control, the memory-enhancing potential of novel N-benzyl pyridine-2-one derivatives was highly significant (P < 0.0001). @*Conclusions@#The observed memory ameliorating effect of novel N-benzyl pyridine-2-one makes them as a a good choice for treatment of individuals with cognitive impairment
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WPRIM
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En
Revista:
Laboratory Animal Research
Ano de publicação:
2024
Tipo de documento:
Article