Incidence and related factors of antiviral drug resistance in HIV-infected pregnant and postpartum women in some areas of three western provinces of China from 2017 to 2019 / 中华预防医学杂志
Chinese Journal of Preventive Medicine
; (12): 1788-1793, 2023.
Article
em Zh
| WPRIM
| ID: wpr-1046262
Biblioteca responsável:
WPRO
ABSTRACT
Objective:
To analyze the incidence and related factors of drug resistance in HIV-infected pregnant and postpartum women in some areas of three western provinces of China from 2017 to 2019.Methods:
From April 2017 to April 2019, face-to-face questionnaires and blood sample testing were conducted in all health care institutions providing maternal and perinatal care and midwifery-assisted services in 7 prevention of mother-to-child transmissi project areas in Xinjiang, Yunnan and Guangxi provinces/autonomous regions. Information was collected during the perinatal period and viral load, CD4+T lymphocytes and drug resistance genes were detected at the same time. The multivariate logistic regression model was used to analyze the relationship between different factors and drug resistance in HIV-infected pregnant and postpartum women.Results:
A total of 655 HIV-infected pregnant and postpartum women were included in this study. The incidence of drug resistance was 3.4% (22/655), all of whom were cross-drug resistant. The rate of low, moderate and high drug resistance was 2.1% (14/655), 1.2% (8/655) and 0.8% (5/655), respectively. The drug resistance rate in the people who had previously used antiviral drugs was 1.9% (8/418), and the drug resistance rate in the people who had not used drugs was 5.9% (14/237). The NNRTI drug resistance accounted for 2.8% (18/655) and the NRTI drug resistance rate was 2.5% (16/655). The multivariate logistic regression model showed that the risk of HIV resistance was lower in pregnant women who had previously used antiviral drugs (OR=0.32, 95%CI 0.11-0.76).Conclusion:
Strengthening the management of antiviral drug use and focusing on pregnant and postpartum women who have not previously used antiviral drugs can help reduce the occurrence of drug-resistant mutations. Personalized antiviral therapy should be considered to achieve viral inhibition effects in clinical practice.
Texto completo:
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Índice:
WPRIM
Assunto principal:
Antivirais
/
Infecções por HIV
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China
/
Incidência
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Transmissão Vertical de Doenças Infecciosas
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Farmacorresistência Viral
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Período Pós-Parto
Limite:
Female
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Humans
/
Pregnancy
País/Região como assunto:
Asia
Idioma:
Zh
Revista:
Chinese Journal of Preventive Medicine
Ano de publicação:
2023
Tipo de documento:
Article