Effects of natural eggshell membrane (NEM) on monosodium iodoacetate-induced arthritis in rats / 한국영양학회지
Journal of Nutrition and Health
; : 310-318, 2015.
Article
em Ko
| WPRIM
| ID: wpr-10567
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE: The aim of this study is to investigate anti-arthritis activity using natural eggshell membrane (NEM). METHODS: NEM was administered at 52 mg/kg, 200 mg/kg, and 400 mg/kg to SD-Rat, where arthritis was induced by monosodium iodoacetate (MIA) at 3 mg. NO production in serum was measured using Griess reagent. Cytokines including IL-1beta, and IL-6 were measured by Luminex and PGE2, MMP-2, MMP-9, TIMP-1, LTB4, and hs-CRP were measured by ELISA. The cartilage of patella volume was examined and 3-D high-resolution reconstructions of the cartilage of patella were obtained using a Micro-CT system. RESULTS: Production of NO, IL-1beta, IL-6, PGE2, MMP-2, MMP-9, TIMP-1, LTB4, and hs-CRP in serum was decreased, respectively, in comparison with control. The cartilage of patella volume increased significantly. In addition, the NEM group showed a decrease in the cartilage of patella, synovial membrane, and transformation of fibrous tissue. CONCLUSION: The results for NEM showed significant anti-arthritis activity. These results may be developed as a raw material for new health food to ease the symptoms mentioned above.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Osteoartrite
/
Patela
/
Artrite
/
Membrana Sinovial
/
Ensaio de Imunoadsorção Enzimática
/
Dinoprostona
/
Cartilagem
/
Citocinas
/
Interleucina-6
/
Leucotrieno B4
Limite:
Animals
Idioma:
Ko
Revista:
Journal of Nutrition and Health
Ano de publicação:
2015
Tipo de documento:
Article