Insulin effect on bupivacaine-induced cardiotoxicity in rabbits / 대한마취과학회지
Korean Journal of Anesthesiology
; : 493-498, 2011.
Article
em En
| WPRIM
| ID: wpr-106333
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND: Resuscitation following bupivacaine-induced cardiovascular collapse is difficult and often refractory to conventional treatment. This study was performed to assess the effect of insulin on bupivacaine-induced cardiovascular collapse in pentobarbital-anesthetized rabbits. METHODS: Bupivacaine was administered at 0.75 mg/kg/min until the heart rate decreased to 65 beats/min. A bolus of regular insulin (2 U/kg) was administered intravenously at the bupivacaine infusion endpoint (BIE) in the insulin group (n = 8), and 2 mL of 0.9% NaCl was administered to the control group (n = 8). RESULTS: All animals in the insulin group survived and four animals died in the control group. Arrythymia was rare 10 minutes after the BIE in the insulin group. CONCLUSIONS: Bupivacaine-induced cardiovascular collapse can be effectively reversed with an insulin injection, probably through facilitation of cardiac conduction and contraction.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Arritmias Cardíacas
/
Ressuscitação
/
Bupivacaína
/
Contratos
/
Frequência Cardíaca
/
Insulina
Limite:
Animals
Idioma:
En
Revista:
Korean Journal of Anesthesiology
Ano de publicação:
2011
Tipo de documento:
Article