Fragile X Premutation in Patients with Idiopathic Premature Ovarian Failure / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
; : 978-983, 2003.
Article
em Ko
| WPRIM
| ID: wpr-107127
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE:
To explore the incidence of fragile X premutation in patients with idiopathic premature ovarian failure, particularly in the Korean population.DESIGN:
A prospective study. MATERIALS ANDMETHODS:
Eighty-three women affected by idiopathic premature ovarian failure were recruited for this study. Patient with known causes of premature ovarian failure were excluded cytogenetic abnormalities, prior chemotherapy, prior bilateral oophorectomy. DNA was extracted from peripheral blood. Fragile X (FRAXA) premutation was evaluated by PCR amplification of and Southern blot analysis for FMR1 gene.RESULTS:
The FRAXA premutation was detected in three (3.6%) out of 83 patients with idiopathic premature ovarian failure.CONCLUSION:
This result suggests that fragile X premutation screening is indicated in patients with idiopathic premature ovarian failure, particularly in the Korean population.Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
DNA
/
Ovariectomia
/
Programas de Rastreamento
/
Southern Blotting
/
Reação em Cadeia da Polimerase
/
Incidência
/
Estudos Prospectivos
/
Aberrações Cromossômicas
/
Insuficiência Ovariana Primária
/
Tratamento Farmacológico
Tipo de estudo:
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Screening_studies
Limite:
Female
/
Humans
Idioma:
Ko
Revista:
Korean Journal of Obstetrics and Gynecology
Ano de publicação:
2003
Tipo de documento:
Article