Sodium tanshinone IIA sulfonate attenuates angiotensin II-induced collagen type I expression in cardiac fibroblasts in vitro
Experimental & Molecular Medicine
; : 508-516, 2009.
Article
em En
| WPRIM
| ID: wpr-107285
Biblioteca responsável:
WPRO
ABSTRACT
Cardiac fibrosis occurs after pathological stimuli to the cardiovascular system. One of the most important factors that contribute to cardiac fibrosis is angiotensin II (Ang II). Accumulating studies have suggested that reactive oxygen species (ROS) plays an important role in cardiac fibrosis and sodium tanshinone IIA sulfonate (STS) possesses antioxidant action. We therefore examined whether STS depresses Ang II-induced collagen type I expression in cardiac fibroblasts. In this study, Ang II significantly enhanced collagen type I expression and collagen synthesis. Meanwhile, Ang II depressed matrix metalloproteinase-1 (MMP-1) expression and activity. These responses were attenuated by STS. Furthermore, STS depressed the intracellular generation of ROS, NADPH oxidase activity and subunit p47(phox) expression. In addition, N-acetylcysteine the ROS scavenger, depressed effects of Ang II in a manner similar to STS. In conclusion, the current studies demonstrate that anti-fibrotic effects of STS are mediated by interfering with the modulation of ROS.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Fenantrenos
/
Acetilcisteína
/
Angiotensina II
/
Medicamentos de Ervas Chinesas
/
Células Cultivadas
/
Western Blotting
/
Sequestradores de Radicais Livres
/
Espécies Reativas de Oxigênio
/
Ratos Wistar
/
Estresse Oxidativo
Limite:
Animals
Idioma:
En
Revista:
Experimental & Molecular Medicine
Ano de publicação:
2009
Tipo de documento:
Article