Induced Pluripotent Stem Cells as a Novel Tool in Psychiatric Research
Psychiatry Investigation
; : 8-17, 2016.
Article
em En
| WPRIM
| ID: wpr-108188
Biblioteca responsável:
WPRO
ABSTRACT
Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) provides a valuable opportunity to study neurodevelopmental and neurodegenerative psychiatric diseases by offering an unlimited source for patient-specific neuronal and glial cells. The present review focuses on the recent advancements in modeling psychiatric disorders such as Phelan-McDermid syndrome, Timothy syndrome, Rett syndrome, schizophrenia, bipolar disorder, and dementia. The treatment effects identified in studies on iPSCs using known therapeutic compounds are also summarized in this review. Here we discuss validation of cellular models and explore iPSCs as a novel drug screening tool. Although there are several limitations associated with the current methods used to study mental disorders, using iPSCs as a model system provides the advantage of rewinding and reviewing the development and degeneration of human neural cells.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Esquizofrenia
/
Transtorno Bipolar
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Síndrome de Rett
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Neuroglia
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Demência
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Avaliação Pré-Clínica de Medicamentos
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Células-Tronco Pluripotentes Induzidas
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Transtornos Mentais
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Neurônios
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Revista:
Psychiatry Investigation
Ano de publicação:
2016
Tipo de documento:
Article