Differential brain angiotensin-II type I receptor expression in hypertensive rats
Journal of Veterinary Science
; : 291-293, 2011.
Article
em En
| WPRIM
| ID: wpr-108423
Biblioteca responsável:
WPRO
ABSTRACT
Blood-borne angiotensin-II (Ang-II) has profound effects in the brain. We tested the hypothesis that Ang-II-dependent hypertension involves differential Ang-II type I (AT1) receptors expression in the subfornical organ (SFO) and the rostral ventrolateral medulla (RVLM). Male Wistar rats were implanted with 14-day osmotic minipump filled with Ang-II (150 ng/kg/min) or saline. AT1 receptor mRNA levels were detected in the SFO and RVLM by reverse transcription-polymerase chain reaction (RT-PCR). Ang-II caused hypertension (134 +/- 10 mmHg vs. 98 +/- 9 mmHg, n = 9, p < 0.05). RT-PCR revealed that Ang-II infusion induced increased AT1 receptor mRNA levels in RVLM and decreased in SFO. Our data suggest that Ang-II-induced hypertension involves differential expression of brain AT1 receptors.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Órgão Subfornical
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RNA Mensageiro
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Angiotensina II
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Bulbo
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Transdução de Sinais
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Ratos Wistar
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Reação em Cadeia da Polimerase Via Transcriptase Reversa
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Receptor Tipo 1 de Angiotensina
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Hipertensão
Limite:
Animals
Idioma:
En
Revista:
Journal of Veterinary Science
Ano de publicação:
2011
Tipo de documento:
Article