Using Sirolimus for Posttransplant Management and Reduction of Tuberous Sclerosis Complex Progression in a Patient with End Stage Renal Disease Caused by Tuberous Sclerosis Complex / 대한이식학회지
The Journal of the Korean Society for Transplantation
; : 241-245, 2014.
Article
em Ko
| WPRIM
| ID: wpr-111534
Biblioteca responsável:
WPRO
ABSTRACT
Tuberous sclerosis complex (TSC) is a neurocutaneous disease characterized by the formation of hamartomas in multiple organs. TSC can show lesions including facial angiofibroma, shagreen patch on the skin, cortical tuber, subependymal nodule, astrocytoma in the brain, cardiac rhabdomyoma, and renal angiomyolipoma. In particular, renal angiomyolipoma may be a cause of end-stage renal disease (ESRD). On the other hand, sirolimus has regulatory effects on cellular growth and proliferation via its inhibitory effect on a protein, mammalian target of rapamycin. We report on a case of an 18-year-old male who underwent renal transplantation due to ESRD induced by TSC. Sirolimus played a role in successful treatment of TSC and effective immunosuppression for transplantation.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Rabdomioma
/
Astrocitoma
/
Pele
/
Esclerose Tuberosa
/
Encéfalo
/
Terapia de Imunossupressão
/
Transplante de Rim
/
Angiomiolipoma
/
Angiofibroma
/
Sirolimo
Limite:
Adolescent
/
Humans
/
Male
Idioma:
Ko
Revista:
The Journal of the Korean Society for Transplantation
Ano de publicação:
2014
Tipo de documento:
Article