Clinical Implications of the Serum Apelin Level on Portal Hypertension and Prognosis of Liver Cirrhosis
Gut and Liver
; : 109-116, 2016.
Article
em En
| WPRIM
| ID: wpr-111610
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND/AIMS:
Levels of serum apelin (s-apelin), an endogenous ligand for angiotensin-like receptor 1, have been shown to be related to hepatic fibrosis and hemodynamic abnormalities in preclinical studies. We investigated the clinical implications of s-apelin as a noninvasive prognostic biomarker for chronic liver disease (CLD).METHODS:
From January 2009 to December 2012, 215 CLD patients were enrolled and underwent clinical data collection, hepatic venous pressure gradient (HVPG) measurement, and liver biopsy. s-apelin was detected with a human total apelin enzyme-linked immunosorbent assay kit. All patients were prospectively observed during the median follow-up period of 23.0±12.9 months for decompensation and mortality.RESULTS:
A total of 42 patients (19.5%) died during the follow-up period. s-apelin was significantly correlated with measurements of liver stiffness (R2=0.263, p<0.001) and collagen proportional area (R2=0.213, p<0.001) measured from liver biopsy tissue and HVPG (R2=0.356, p<0.001). In a multivariate analysis using a Cox regression hazard model, s-apelin was a weakly significant predictor of decompensation (hazard ratio [HR], 1.002; p<0.001) and mortality (HR, 1.003; p<0.001).CONCLUSIONS:
s-apelin showed a significant relationship with CLD severity. However, its significance as a noninvasive biomarker for disease severity and prognosis was weak.Palavras-chave
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Assunto principal:
Prognóstico
/
Biópsia
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Ensaio de Imunoadsorção Enzimática
/
Biomarcadores
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Modelos de Riscos Proporcionais
/
Estudos Prospectivos
/
Seguimentos
/
Pressão na Veia Porta
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Peptídeos e Proteínas de Sinalização Intercelular
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Hipertensão Portal
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
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Female
/
Humans
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Male
Idioma:
En
Revista:
Gut and Liver
Ano de publicação:
2016
Tipo de documento:
Article