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Effects of propofol on beta-adrenoceptor-mediated signal transduction in cardiac muscle; role of cAMP / 대한마취과학회지
Article em En | WPRIM | ID: wpr-11416
Biblioteca responsável: WPRO
ABSTRACT

BACKGROUND:

Propofol may decrease myocardial contractility via actions on the beta-adrenoceptor-mediated signal transduction. The aim of this study was to evaluate the effect of propofol via beta-adrenoceptor-mediated signal transduction by measuring the tissue levels of cAMP (cyclic adenosine monophosphate).

METHODS:

The effects of propofol on beta-adrenoceptor mediated cascades were measured with cAMP concentrations, which were stimulated by agonists (l-isoproterenol, GTPgammaS, and forskolin) of each step of beta-adrenoceptor-mediated cascades.

RESULTS:

While the production of cAMP stimulated by isoproterenol, GTPgammaS, or forskolin are increased (P < 0.05), application of each concentration of propofol (0.1, 1, 10, 100 micrometer) did not alter the levels of cAMP.

CONCLUSIONS:

Considering that propofol did not alter the tissue cAMP levels when stimulated by isoproterenol, GTPgammaS, and forskolin, propofol appears to have no effect on the beta-adrenoceptor signaling pathway in guinea pig ventricular myocardium.
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Texto completo: 1 Índice: WPRIM Assunto principal: Colforsina / Transdução de Sinais / Propofol / Adenosina / Guanosina 5&apos;-O-(3-Tiotrifosfato) / Proteínas de Ligação ao GTP / Cobaias / Isoproterenol / Miocárdio Limite: Animals Idioma: En Revista: Korean Journal of Anesthesiology Ano de publicação: 2010 Tipo de documento: Article
Texto completo: 1 Índice: WPRIM Assunto principal: Colforsina / Transdução de Sinais / Propofol / Adenosina / Guanosina 5&apos;-O-(3-Tiotrifosfato) / Proteínas de Ligação ao GTP / Cobaias / Isoproterenol / Miocárdio Limite: Animals Idioma: En Revista: Korean Journal of Anesthesiology Ano de publicação: 2010 Tipo de documento: Article