Effects of propofol on beta-adrenoceptor-mediated signal transduction in cardiac muscle; role of cAMP / 대한마취과학회지
Korean Journal of Anesthesiology
; : 374-377, 2010.
Article
em En
| WPRIM
| ID: wpr-11416
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND:
Propofol may decrease myocardial contractility via actions on the beta-adrenoceptor-mediated signal transduction. The aim of this study was to evaluate the effect of propofol via beta-adrenoceptor-mediated signal transduction by measuring the tissue levels of cAMP (cyclic adenosine monophosphate).METHODS:
The effects of propofol on beta-adrenoceptor mediated cascades were measured with cAMP concentrations, which were stimulated by agonists (l-isoproterenol, GTPgammaS, and forskolin) of each step of beta-adrenoceptor-mediated cascades.RESULTS:
While the production of cAMP stimulated by isoproterenol, GTPgammaS, or forskolin are increased (P < 0.05), application of each concentration of propofol (0.1, 1, 10, 100 micrometer) did not alter the levels of cAMP.CONCLUSIONS:
Considering that propofol did not alter the tissue cAMP levels when stimulated by isoproterenol, GTPgammaS, and forskolin, propofol appears to have no effect on the beta-adrenoceptor signaling pathway in guinea pig ventricular myocardium.Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Colforsina
/
Transdução de Sinais
/
Propofol
/
Adenosina
/
Guanosina 5'-O-(3-Tiotrifosfato)
/
Proteínas de Ligação ao GTP
/
Cobaias
/
Isoproterenol
/
Miocárdio
Limite:
Animals
Idioma:
En
Revista:
Korean Journal of Anesthesiology
Ano de publicação:
2010
Tipo de documento:
Article