Your browser doesn't support javascript.
loading
Cord Blood Cellular Proliferative Response as a Predictive Factor for Atopic Dermatitis at 12 Months
Article em En | WPRIM | ID: wpr-128870
Biblioteca responsável: WPRO
ABSTRACT
Since the risk of developing allergic disease increases in individuals exposed to allergens previously, even during the neonatal period, the immunologic status of a fetus may be important in the subsequent development of allergy. We evaluated the fetal factors to predict atopic dermatitis (AD) at 12 months in 412 infants of a COhort for Childhood Origin of Asthma and Allergic Diseases (COCOA) in the general Korean population. Cord blood mononuclear cells (CBMCs) were stimulated with ovalbumin and phytohemagglutinin and cellular proliferative response and concentrations of interleukin-13 and interferon-gamma, were measured. The risk of developing AD was greater in boys than girls (OR 1.97, 95% CI 1.26-3.09), infants delivered by cesarean section than vaginally (OR 1.93, 95% CI 1.14-3.26) and infants with than without parental history of AD (OR 2.34, 95% CI 1.29-4.24). The CBMC proliferative response to phytohemagglutinin stimulation was higher in infants with than without AD (P = 0.048), but no difference was observed in ovalbumin-stimulated cells (P = 0.771). Risk factors for the development of AD at 12 months include male gender, delivery by cesarean section and parental history of AD. Increased CBMC proliferative response to phytohemagglutinin stimulation may predict the development of AD at 12 months.
Assuntos
Palavras-chave
Texto completo: 1 Índice: WPRIM Assunto principal: Fito-Hemaglutininas / Leucócitos Mononucleares / Razão de Chances / Cesárea / Ovalbumina / Fatores Sexuais / Valor Preditivo dos Testes / Fatores de Risco / Interferon gama / Interleucina-13 Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Infant / Male / Pregnancy Idioma: En Revista: Journal of Korean Medical Science Ano de publicação: 2012 Tipo de documento: Article
Texto completo: 1 Índice: WPRIM Assunto principal: Fito-Hemaglutininas / Leucócitos Mononucleares / Razão de Chances / Cesárea / Ovalbumina / Fatores Sexuais / Valor Preditivo dos Testes / Fatores de Risco / Interferon gama / Interleucina-13 Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Infant / Male / Pregnancy Idioma: En Revista: Journal of Korean Medical Science Ano de publicação: 2012 Tipo de documento: Article