Effects of Postoperative Radiotherapy on Leptomeningeal Carcinomatosis or Dural Metastasis after Resection of Brain Metastases in Breast Cancer Patients / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
; : 748-758, 2017.
Article
em En
| WPRIM
| ID: wpr-129238
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE:
In this retrospective study, we compared the incidence of leptomeningeal carcinomatosis or dural metastasis (LMCDM) in patients who received whole brain radiotherapy (WBRT), partial radiotherapy (PRT), or no radiotherapy (RT) following resection of brain metastases from breast cancer. MATERIALS ANDMETHODS:
Fifty-one patients with breast cancer underwent surgical resection for newly diagnosed brain metastases in two institutions between March 2001 and March 2015. Among these, 34 received postoperative WBRT (n=24) or PRT (n=10) and 17 did not.RESULTS:
With a median follow-up of 12.4 months (range, 2.3 to 83.6 months), 22/51 patients developed LMCDM at a median of 8.6 months (range, 4.8 to 51.2 months) after surgery. The 18-months LMCDM-free survival (LMCDM-FS) rates were 77.5%, 30.0%, and 13.6%, in the WBRT, PRT, and no RT groups, respectively (p=0.013). The presence of a tumor adjacent to cerebrospinal fluid flow and no systemic treatment after treatment for brain metastases were also associated with poor LMCDM-FS rate. Multivariate analysis showed that WBRT compared to PRT (p=0.009) and systemic treatment (p < 0.001) were independently associated with reduced incidence of LMCDM.CONCLUSION:
WBRT improved LMCDM-FS rate after resection of brain metastases compared to PRT in breast cancer patients.Palavras-chave
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WPRIM
Assunto principal:
Radioterapia
/
Encéfalo
/
Mama
/
Neoplasias da Mama
/
Líquido Cefalorraquidiano
/
Incidência
/
Análise Multivariada
/
Estudos Retrospectivos
/
Seguimentos
/
Carcinomatose Meníngea
Tipo de estudo:
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Cancer Research and Treatment
Ano de publicação:
2017
Tipo de documento:
Article